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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

Question 1

A clinical microbiology laboratory is investigating a potential outbreak of Legionella pneumophila associated with a hospital's water system. The MOST appropriate environmental samples to collect for culture and comparison to clinical isolates would be:

A. Surface swabs from frequently touched objects.
B. Water samples from showers, faucets, and cooling towers.
C. Sputum samples from asymptomatic healthcare workers.
D. Air samples from patient rooms and common areas.

Question 2

A patient with HIV infection and a CD4+ T-cell count below 50 cells/µL develops a progressive neurological illness characterized by confusion, motor deficits, and seizures. Brain MRI reveals multiple white matter lesions without mass effect. PCR of the CSF is positive for JC virus. Thepathogenesis of this condition, progressive multifocal leukoencephalopathy (PML), involves:

A. Lytic infection of oligodendrocytes by JC virus, leading to demyelination.
B. Opportunistic infection by JC virus due to impaired cell-mediated immunity.
C. Inflammatory demyelination triggered by JC virus infection of astrocytes.
D. Direct cytopathic effect of JC virus on neurons.

Question 3

A clinical microbiology laboratory is investigating a cluster of Clostridium difficile infections in a hospital.
Which of the following methods is MOST appropriate for determining if the isolates from different patients are related?

A. Enzyme immunoassay for C. difficile toxins
B. Gram staining and morphology
C. Molecular typing (e.g., PCR ribotyping)
D. Antimicrobial susceptibility testing

Question 4

A patient with a history of travel to a tropical region presents with cyclical fevers and chills.Peripheral blood smear reveals the presence of merozoites and schizonts within erythrocytes. The absence of crescent-shaped gametocytes makes Plasmodium falciparum less likely. The MOST probable species is:

A. Plasmodium knowlesi
B. Plasmodium vivax
C. Plasmodium malariae
D. Plasmodium ovale

Question 5

A research laboratory is investigating the mechanisms of antiviral drug resistance. They are studying a herpes simplex virus strain that has developed resistance to acyclovir. The MOST common mechanism of acyclovir resistance in HSV involves mutations in the gene encoding:

A. Viral DNA polymerase
B. Viral thymidine kinase
C. Viral protease
D. Viral glycoprotein D

Solutions: